Neurotrophins, synaptic plasticity and dementia

@article{Arancio2007NeurotrophinsSP,
  title={Neurotrophins, synaptic plasticity and dementia},
  author={Ottavio Arancio and Moses V Chao},
  journal={Current Opinion in Neurobiology},
  year={2007},
  volume={17},
  pages={325-330}
}
Brain‐derived neurotrophic factor and the development of structural neuronal connectivity
TLDR
An overview of the possible actions ofBDNF in the development of neural circuits, with an emphasis on presynaptic actions of BDNF during the structural development of central neurons.
The Neurotrophins and Their Role in Alzheimer’s Disease
TLDR
The pathology, symptoms and molecular processes associated with Alzheimer’s disease are described and the involvement of the neurotrophins, particularly NGF and BDNF, and their receptors, are discussed, with changes in BDNF considered particularly in the light of its importance in synaptic plasticity.
Brain-Derived Neurotrophic Factor: Linking Fear Learning to Memory Consolidation
TLDR
The molecular cascade by which fear learning leads to an increase in BDNF expression in the lateral amygdala (LA) is described, which contributes to fear memory consolidation.
Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function
TLDR
Using a high‐density microarray platform, a significant decrease in genes that are associated with vesicular trafficking and synaptic function are identified, as well as selective increases in MAP kinase phosphatases that are relevant to a wide number of conditions in which levels of BDNF are compromised.
Is Altered BDNF Biosynthesis a General Feature in Patients with Cognitive Dysfunctions?
TLDR
The hypothesis that abnormalities in proBDNF or mBDNF biosynthesis may correspond to different cognitive dysfunctions in these brain diseases, while the role of truncated BDNF remains unknown is put forward.
Synaptic regulation of affective behaviors; role of BDNF
  • I. Ninan
  • Biology, Psychology
    Neuropharmacology
  • 2014
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...

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