Neurotrophin signaling through the p75 neurotrophin receptor

@article{Roux2002NeurotrophinST,
  title={Neurotrophin signaling through the p75 neurotrophin receptor},
  author={Philippe P Roux and Philip A. Barker},
  journal={Progress in Neurobiology},
  year={2002},
  volume={67},
  pages={203-233}
}
Mechanisms of neurotrophin receptor signalling.
TLDR
The p75 receptor participates with the TrkA receptor in the formation of high-affinity nerve growth factor-binding sites to promote survival under limiting concentrations of neurotrophins.
Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease
TLDR
Future studies hold the promise of revealing a wealth of information on the multifaceted actions of the p75NTR that will inform the design of new neurotrophin-based therapies.
Interaction between the p75 neurotrophin receptor and a novel adaptor protein
TLDR
This study found out that the intracellular domain of the p75 neurotrophin receptor was important for the interaction with ARMS, and suggests that ARMS may play an important role for mediating the signals from p75 neuropeptide receptor into the cell.
Neurotrophin Signaling through the p75 Receptor Is Deficient in traf6-/- Mice
TLDR
TRAF6 plays an essential role in mediating p75 signal transduction and induction of apoptosis, and deficiencies in p75 signaling in traf6-/- animals resulted in a loss of p75-mediated apoptosis.
Activation of the mitogen‐activated protein kinase pathway through p75NTR: A common mechanism for the neurotrophin family
TLDR
The results of this study support the concept that signaling from the p75NTR receptor is more diverse and extensive than previously believed.
TrkA Receptor Activation by Nerve Growth Factor Induces Shedding of the p75 Neurotrophin Receptor Followed by Endosomal γ-Secretase-mediated Release of the p75 Intracellular Domain*
TLDR
It is demonstrated that activation of the TrkA receptor upon binding of nerve growth factor (NGF) regulates the metalloprotease-mediated shedding of p75 leaving a membrane-bound p75 C-terminal fragment (p75-CTF), and NGF-induced endocytosis regulates both signaling and proteolytic processing of p 75.
Neurotrophin Effects on Neuroblastoma Cells: Correlation with Trk and p75NTR Expression and Influence of Trk Receptor Bodies
TLDR
The results indicate that p75NTR activation has diverse effects on neuroblastomas, depending on the specific neuroblastoma clone, and point towards TrkB-Fc or TrkC-fc receptor bodies as useful tools to influence the survival of neuro Blastoma cells.
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References

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Neurotrophins: the biological paradox of survival factors eliciting apoptosis
TLDR
The unique features and implications of the p75NTR signal transduction system, in which life-death decisions of cells are dependent upon the expression and action of two different receptors with distinctive signaling mechanisms, are discussed.
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
TLDR
Results indicate that TrkA-mediated rescue involves not only activation of survival signals but also simultaneous suppression of a death signal by p75, a novel mechanism that achieves alternative cellular responses by merging signals from different ligand–receptor systems.
Association of the p75 Neurotrophin Receptor with TRAF6*
TLDR
A specific interaction between p75 and TRAF6 (tumor necrosis factorreceptor-associated factor-6) after transient transfection in HEK293T cells is reported, indicating that TRAF 6 can potentially function as a signal transducer for NGF actions through the p75 receptor.
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
TLDR
A close proximity of the two neurotrophin receptors within cell membranes is indicated, and it is suggested that the signalling pathways they initiate may interact soon after their activation.
Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons
TLDR
It is proposed that a neurotrophin–p75NTR–ceramide signaling pathway influences outgrowth of hippocampal neurons and may be distinct from other signaling pathways that lead to apoptosis.
p75NTR: A study in contrasts
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TLDR
In cells lacking trk expression, p75NTR can act autonomously to activate ligand-dependent signaling cascades that may in some circumstances result in apoptosis but probably not through pathways utilized by its apoptotic brethren in the TNF receptor superfamily.
The p75 neurotrophin receptor and neuronal apoptosis
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TLDR
Characterization of mutant mice lacking each of these tyrosine-kinase receptors by gene targeting in embryonic stem cells is providing relevant information regarding the critical role that these receptors play in the ontogeny of the mammalian nervous system.
Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor
TLDR
It is demonstrated for the first time that all four members of the neurotrophin family directly elicit the death of hippocampal neurons via the p75 receptor, demonstrating that neurotrophins can regulate death as well as survival of CNS neurons.
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