Neurotrophin signaling endosomes: biogenesis, regulation, and functions

@article{Yamashita2016NeurotrophinSE,
  title={Neurotrophin signaling endosomes: biogenesis, regulation, and functions},
  author={Naoya Yamashita and Rejji Kuruvilla},
  journal={Current Opinion in Neurobiology},
  year={2016},
  volume={39},
  pages={139-145}
}
In the nervous system, communication between neurons and their post-synaptic target cells is critical for the formation, refinement and maintenance of functional neuronal connections. Diffusible signals secreted by target tissues, exemplified by the family of neurotrophins, impinge on nerve terminals to influence diverse developmental events including neuronal survival and axonal growth. Key mechanisms of action of target-derived neurotrophins include the cell biological processes of… CONTINUE READING
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