Neurotrophin signal transduction in medulloblastoma.

  title={Neurotrophin signal transduction in medulloblastoma.},
  author={Thomas Chou and John Q. Trojanowski and Virginia M-Y Lee},
  journal={Journal of neuroscience research},
  volume={49 5},
The members of the neurotrophin family play key biological roles in the development of the nervous system. Based on studies initially in cell lines (e.g., the rat pheochromocytoma PC12 cells), neurotrophins have been found to be important mediators of proliferation, differentiation, and survival in the normal brain, but their role in brain tumors remains unclear. Since neurotrophins and neurotrophin receptors are frequently detected in biopsy samples of central nervous system medulloblastomas… CONTINUE READING


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