Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells.

@article{Kim2003NeurotrophinregulatedSO,
  title={Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells.},
  author={K A Kim and Mark von Zastrow},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 6},
  pages={2075-85}
}
Neurotrophins modulate the endogenous opioid system, but the underlying mechanisms are poorly understood. We observed an unexpected effect of neurotrophin signaling on the membrane trafficking of recombinant opioid receptors expressed in neurosecretory cells. Epitope-tagged delta opioid receptor (DOR) and mu opioid receptor (MOR) were differentially localized between surface and internal membrane pools, respectively, when expressed in primary cultured hippocampal neurons, consistent with… CONTINUE READING

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