Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease.

@article{Boissiere1996NeurotrophinRA,
  title={Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease.},
  author={F. Boissiere and St{\'e}phane Leh{\'e}ricy and Ornella Strada and Yves Agid and Etienne C. Hirsch},
  journal={Molecular and chemical neuropathology},
  year={1996},
  volume={28 1-3},
  pages={
          219-23
        }
}
The most consistent neuropathological finding in Alzheimer disease (AD) is the loss of cholinergic neurons of the nucleus basalis of Meynert (NbM). Using immunohistochemistry, we have previously shown that cholinergic neurons located in the ventral striatum were affected, whereas those of the caudate nucleus, putamen, and mesencephalon were spared. Since cholinergic neurons that degenerate in AD are sensitive to NGF and those that are spared are not, it has been hypothesized that the loss of… CONTINUE READING
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