Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy

@article{Pramanik2016NeurotrophinSA,
  title={Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy},
  author={Subrata Pramanik and Yanuar Alan Sulistio and Klaus Heese},
  journal={Molecular Neurobiology},
  year={2016},
  volume={54},
  pages={7401-7459}
}
Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 NT receptor (p75NTR), a member of the tumor necrosis factor (TNF) receptor family. Although NTs were first discovered in neurons, recent studies have suggested that NTs and their receptors are expressed in various types of stem cells mediating pivotal signaling events in stem cell biology. The concept of stem cell… CONTINUE READING

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