Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth

@article{Yamashita1999NeurotrophinBT,
  title={Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth},
  author={Toshihide Yamashita and Kerry L Tucker and Yves-Alain Barde},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={585-593}
}

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Signalling through the neurotrophin receptor p75NTR
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TLDR
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A specific interaction between p75 and TRAF6 (tumor necrosis factorreceptor-associated factor-6) after transient transfection in HEK293T cells is reported, indicating that TRAF 6 can potentially function as a signal transducer for NGF actions through the p75 receptor.
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In the absence of TrkA, NGF binding to p75NGR activated the transcription factor nuclear factor kappa B (NF-kappa B) in rat Schwann cells, and the effect was selective for NGF; NF-Kappa B was not activated by BDNF or NT-3.
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TLDR
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The number of neurons in the adult nervous system and the density of innervation of their targets are determined by a competitive process in which tissues produce trophic factors that support neuronal survival.
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