Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity.

@article{Zheng1995Neurotrophin45ES,
  title={Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity.},
  author={J. Lisa Zheng and Randall R. Stewart and Wei Qiang Gao},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 7 Pt 2},
  pages={5079-87}
}
Destruction of spiral ganglion neurons (SGNs) induced by injury and toxins is one of the major causes for hearing loss. Here we report that neurotrophin-4/5 (NT-4/5), a member of the nerve growth factor family, promoted survival of postnatal rat SGNs up to threefold in dissociated cell cultures. The survival-promoting potency of NT-4/5 was equivalent to that of BDNF and stronger than that of NT-3. In contrast, NGF showed no detectable effects. Immunohistochemistry, with TrkB and TrkA antisera… CONTINUE READING

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Human trks: mo

  • DL Shelton, J Sutherland, +6 authors AD Levinson
  • 1995

BjBrklund A (1994) Reversal of spatial memory impairments in aged rats by nerve growth

  • W Fischer, A Sirevaag, SJ Wiegand, RM Lindsay
  • Nature
  • 1994
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