Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.

@article{Sayers2003Neurotrophin3PT,
  title={Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.},
  author={Nicola M Sayers and Lisa J Beswick and Alicia B Middlemas and Nigel A. Calcutt and Andrew P. Mizisin and David Richard Tomlinson and Paul Fernyhough},
  journal={Diabetes},
  year={2003},
  volume={52 9},
  pages={2372-80}
}
The relation between neurofilament expression and/or phosphorylation in the proximal versus distal components of the sensory peripheral neuraxis was studied and related to disorders in structure and function of the distal axon of streptozocin (STZ)-induced diabetic rats studied for 14 weeks. The ability of neurotrophin-3 (NT-3) to prevent abnormalities in neurofilament biology was also investigated. Compared with age-matched controls, neurofilament heavy (NF-H) (3.3-fold) and neurofilament… CONTINUE READING

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