Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis

@article{Louie2013Neurotrophin3MB,
  title={Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis},
  author={Elizabeth Louie and Xiu Fang Chen and Alexandra Coomes and Kaiyuan Ji and Stella E. Tsirka and Edmund I-T Chen},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={4064-4077}
}
Metastasis, which remains incompletely characterized at the molecular and biochemical levels, is a highly specific process. Despite the ability of disseminated cancer cells to intravasate into distant tissues, it has been long recognized that only a limited subset of target organs develop clinically overt metastases. Therefore, subsequent adaptation of disseminated cancer cells to foreign tissue microenvironment determines the metastatic latency and tissue tropism of these cells. As a result… CONTINUE READING
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