Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms

@article{Je2006Neurotrophin3I,
  title={Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms},
  author={Hyun-Soo Je and Feng Yang and Jiangzheng Zhou and B. F. Lu},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={175},
  pages={1029 - 1042}
}
The mechanisms by which neurotrophins elicit long-term structural and functional changes of synapses are not known. We report the mechanistic separation of functional and structural synaptic regulation by neurotrophin 3 (NT-3), using the neuromuscular synapse as a model. Inhibition of cAMP response element (CRE)-binding protein (CREB)-mediated transcription blocks the enhancement of transmitter release elicited by NT-3, without affecting the synaptic varicosity of the presynaptic terminals… CONTINUE READING

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  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

Distinct mechanisms for neurotrophin-3-induced acute and long-term synaptic potentiation.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2005
VIEW 8 EXCERPTS

Up-regulation of NR2B subunit of NMDA receptors in cerebellar granule neurons by Ca2+/calmodulin kinase inhibitor KN93

L. Corsi, J. H. Li, +3 authors S. Vicini.
  • J. Neurochem. 70:1898–1906.
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Neurotrophins promote maturation of developing neuromuscular synapses.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
VIEW 5 EXCERPTS

Acute and long-term regulation of synapses by neurotrophins

B. Lu
  • Prog. Brain Res. 146:137–150.
  • 2004
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Nerve growth factor activates persistent Rap1 signaling in endosomes.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2001
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

CREB and memory.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL