Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway.

@article{Yamauchi2003Neurotrophin3A,
  title={Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway.},
  author={Junji Yamauchi and Jonah R Chan and Eric M. Shooter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 24},
  pages={14421-6}
}
During development and nerve injury, complex interactions between glial cells and neurons are essential for establishing proper nerve function. Neurotrophins play multiple roles in the developing nervous system, including cell survival, growth, and differentiation. Here we show that migration of Schwann cells, isolated from sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-derived neurotrophic factor. The neurotrophin-3-induced cell migration… CONTINUE READING