Neurotrophin-3 Is Required for the Survival–Differentiation of Subsets of Developing Enteric Neurons

@article{Chalazonitis2001Neurotrophin3IR,
  title={Neurotrophin-3 Is Required for the Survival–Differentiation of Subsets of Developing Enteric Neurons},
  author={A. Chalazonitis and T. Pham and T. P. Rothman and P. Distefano and M. Bothwell and J. Blair-Flynn and L. Tessarollo and M. Gershon},
  journal={The Journal of Neuroscience},
  year={2001},
  volume={21},
  pages={5620 - 5636}
}
Neurotrophin-3 (NT-3) promotes enteric neuronal developmentin vitro; nevertheless, an enteric nervous system (ENS) is present in mice lacking NT-3 or TrkC. We thus analyzed the physiological significance of NT-3 in ENS development. Subsets of neurons developing in vitro in response to NT-3 became NT-3 dependent; NT-3 withdrawal led to apoptosis, selectively in TrkC-expressing neurons. Antibodies to NT-3, which blocked the developmental response of enteric crest-derived cells to exogenous NT-3… Expand
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TLDR
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