Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder.

@article{Murphy2012NeurotrophicTK,
  title={Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder.},
  author={Melissa L. Murphy and Angela Carballedo and Andrew J Fagan and Derek Morris and Ciara Fahey and James Frances Mary Meaney and Thomas Frodl},
  journal={Biological psychiatry},
  year={2012},
  volume={72 8},
  pages={663-70}
}
BACKGROUND Polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and its receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) have been implicated in mood disorders. The aim of this study was to examine whether the NTRK2 and BDNF polymorphisms impact brain white matter connections in major depressive disorder and whether they may also have an interactive effect with environmental stress in the form of early life adversity. METHODS The study group comprised 45 depressed… CONTINUE READING
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