Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.

  title={Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.},
  author={Puei-Lene Lai and Murali Naidu and Vikineswary Sabaratnam and Kah-Hui Wong and Rosie Pamela David and Umah Rani Kuppusamy and Noorlidah Abdullah and Sri Nurestri Abd Malek},
  journal={International journal of medicinal mushrooms},
  volume={15 6},
Neurotrophic factors are important in promoting the growth and differentiation of neurons. Nerve growth factor (NGF) is essential for the maintenance of the basal forebrain cholinergic system. Hericenones and erinacines isolated from the medicinal mushroom Hericium erinaceus can induce NGF synthesis in nerve cells. In this study, we evaluated the synergistic interaction between H. erinaceus aqueous extract and exogenous NGF on the neurite outgrowth stimulation of neuroblastoma-glioma cell NG108… 

Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

The results suggest that hericene A can promote BDNF-like activity in neurons in vitro and in vivo thereby enhancing recognition memory and increased BDNF and downstream pathway and enhanced learning and memory in the novel object recognition memory test.

Hericium erinaceus - A Rich Source of Diverse Bioactive Metabolites

This review provides a comprehensive account of the bioactive compounds from H. erinaceus (both from the fruit bodies and mycelia) and their biological activities such as neuroprotective functions, cytotoxicity, anticarcinogenic, antidiabetic, antimicrobial, and herbicidal activities.

Neurite outgrowth stimulatory effects of myco synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells

AuNPs were shown to have potential neuronal differentiation and stimulated neurite outgrowth and the water-soluble bioconstituents could be responsible for the neuroactivity.

Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways.

It is suggested that hericenone E potentiated NGF-induced neuritogenesis in PC12 cells via the MEK/ERK and PI3K/Akt pathways.

In vitro anti-neuroinflammatory and neuritogenic stimulatory effects of a medicinal mushroom lignosus rhinocerotis (Cooke) ryvarden / Syntyche Seow Ling Sing

Four medicinal mushrooms were evaluated for cytotoxic, inhibition of nitric oxide (NO) production and neuritogenic stimulatory activities in murine BV2 microglial and rat pheochromocytoma cells and the underlying mechanisms were investigated.

High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity

The results demonstrate that HEPS exhibit antioxidant and neuroprotective effects on Aβ-induced neurotoxicity in neurons.

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

These three traditional folk medicinal herbs target the main biochemical events that are implicated in mental disorders, mimicking, to some extent, the mechanisms of action of conventional antidepressants and mood stabilizers with a wide margin of tolerability.

Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism

Over 20 different brain-improving culinary-medicinal mushrooms and at least 80 different bioactive secondary metabolites isolated from them reduced beta amyloid-induced neurotoxicity and had anti-acetylcholinesterase, neurite outgrowth stimulation, nerve growth factor synthesis, neuroprotective, antioxidant, and anti-(neuro)inflammatory effects are reviewed.

Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells

The neuritogenic activity in PC-12 cells stimulated by hot aqueous and ethanolic extracts, and crude polysaccharides of L. rhinocerotis sclerotium mimicking NGF activity via the MEK/ERK1/2 signaling pathway is reported for the first time.

Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action

The findings suggest that H. erinaceus is capable of accelerating sensory functional recovery after peripheral nerve injury and the effect involves the activation of protein kinase signaling pathways and restoration of blood-nerve barrier.