Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons.

@article{Loeb1997NeurotrophicFI,
  title={Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons.},
  author={Jeffrey A. Loeb and Gerald D. Fischbach},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 4},
  pages={1416-24}
}
Neuregulins (NRGs) are expressed in spinal cord motor neurons and accumulate at the neuromuscular junction where they may increase the synthesis of postsynaptic acetylcholine receptors and voltage-gated sodium channels. We demonstrate here that NRG expression is selectively increased in rat ventral spinal cord neurons at approximately the time that nerve-muscle synapses first form. A rapid increase in NRG mRNA and protein expression was induced in vitro in cultured rat spinal motor neurons by… CONTINUE READING

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