Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury.

@article{Logan2006NeurotrophicFS,
  title={Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury.},
  author={Ann Catherine Logan and Zubair Ahmed and Andrew Baird and Ana Maria Gonzalez and Martin Foster Berry},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 2},
  pages={
          490-502
        }
}
The therapeutic effects of individual neurotrophic factors (NTF) have proved disappointing in clinical trials for neuronal repair and axon regeneration. Here, we demonstrate NTF synergistic neuronal responses after a combination of basic fibroblast growth factor, neurotrophin-3 and brain derived growth factor delivered to the somata of retinal ganglion cells promoted greater survival and axon growth than did the sum of the effects of each NTF alone. Triple and not single NTF treatments… CONTINUE READING

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