Neurotrophic effects of BDNF and CNTF, alone and in combination, on postnatal day 5 rat acoustic ganglion neurons.

@article{Hartnick1996NeurotrophicEO,
  title={Neurotrophic effects of BDNF and CNTF, alone and in combination, on postnatal day 5 rat acoustic ganglion neurons.},
  author={Christopher J. Hartnick and Hinrich Staecker and Brigitte Malgrange and Philippe P. Lefebvre and Wei Liu and Gustave Moonen and Thomas R. Van De Water},
  journal={Journal of neurobiology},
  year={1996},
  volume={30 2},
  pages={246-54}
}
The neuronal survival promoting ability of brain derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF), individually and in combination, was evaluated in dissociated cell cultures of postnatal day 5 (P5) rat acoustic ganglia. The neuritogenic promoting effect of these same neurotrophic factors was examined in organotypic explants of P5 rat acoustic ganglia. The results showed that BDNF was maximally effective at a concentration of 10 ng/mL in promoting both survival and… CONTINUE READING