Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro.

@article{Hamanoue1996NeurotrophicEO,
  title={Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro.},
  author={Makoto Hamanoue and Naoya Takemoto and Kayo Matsumoto and Toshikazu Nakamura and Kazuyuki Nakajima and Shinichi Kohsaka},
  journal={Journal of neuroscience research},
  year={1996},
  volume={43 5},
  pages={554-64}
}
Although the expression of hepatocyte growth factor (HGF) and its receptor, proto-oncogene c-met, has been demonstrated in the central nervous system (CNS), the function of HGF in the CNS was not fully understood. In the present studies, we determined the effects of HGF on neuronal development in neocortical explant and mesencephalic neurons obtained from embryonic rat brain. HGF clearly enhanced neurite outgrowth in neocortical explants. In the mesencephalic culture, the number of tyrosine… CONTINUE READING

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