Neurotransmitters in nociceptive modulatory circuits.

@article{Fields1991NeurotransmittersIN,
  title={Neurotransmitters in nociceptive modulatory circuits.},
  author={Howard L Fields and Mary Magdalen Heinricher and Peggy Mason},
  journal={Annual review of neuroscience},
  year={1991},
  volume={14},
  pages={219-45}
}
Significant advances have been made in our understanding of nociceptive modulation from RVM. Among the most useful conceptually has been the discovery that there are two classes of modulatory neurons in the RVM that are likely to have opposing actions on nociception: on-cells, which may facilitate nociceptive transmission, and off-cells, which probably have a net inhibitory effect on nociception. The similarity in response properties among the members of each class, their large, somatic… CONTINUE READING
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Other possible connections are based on more limited data ; however , ACh , neurotensin , NE , and EAAs are present in neurons that project to the RVM , and each of these compounds , when microinjected into the RVM , has a modulating effect on nociceptive transmission .
Other possible connections are based on more limited data ; however , ACh , neurotensin , NE , and EAAs are present in neurons that project to the RVM , and each of these compounds , when microinjected into the RVM , has a modulating effect on nociceptive transmission .
At the level of the dorsal horn , there is good evidence for each of three inhibitory mechanisms : direct inhibition of nociceptive projection neurons , inhibition of excitatory relay interneurons , and excitation of an inhibitory interneuron .
At the level of the dorsal horn , there is good evidence for each of three inhibitory mechanisms : direct inhibition of nociceptive projection neurons , inhibition of excitatory relay interneurons , and excitation of an inhibitory interneuron .
At the level of the dorsal horn , there is good evidence for each of three inhibitory mechanisms : direct inhibition of nociceptive projection neurons , inhibition of excitatory relay interneurons , and excitation of an inhibitory interneuron .
At the level of the dorsal horn , there is good evidence for each of three inhibitory mechanisms : direct inhibition of nociceptive projection neurons , inhibition of excitatory relay interneurons , and excitation of an inhibitory interneuron .
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