Neurotransmitter synthesis in inner ear and lateral line sense organs

@article{Flock1974NeurotransmitterSI,
  title={Neurotransmitter synthesis in inner ear and lateral line sense organs},
  author={Ake Flock and Dominic Man-Kit Lam},
  journal={Nature},
  year={1974},
  volume={249},
  pages={142-144}
}
HAIR cells of inner ear sense organs and of lateral line organs in fish are innervated by afferent nerve fibres, to which they transmit information about mechanical stimuli. Efferent inhibitory nerve fibres, which originate in the central nervous system, also innervate most hair cells at their base (Fig. 1b). Recent evidence indicates that both these synapses are chemical; excitatory postsynaptic potentials (e.p.s.p.s) have been recorded in afferent nerve terminals in response to mechanical… 

Information Transfer at the Synapse between Hair Cells and Sensory Nerve Fibres

The most common type of hair cell is dealt with, that which has afferent and efferent nerve endings side by side innervating the hair cell base, designed commonly as Type II hair cells (Wersall, 1956).

Inhibition by efferent nerve fibres: action on hair cells and afferent synaptic transmission in the lateral line canal organ of the burbot Lota lota.

Intracellular recordings were made from morphologically identified hair cells in the lateral line canal organs of the burbot Lota lota when the efferent fibres were excited by electrical stimulation of theateral line nerve and the i.p.s.s were abolished when the fish was injected with immobilizing concentration of Flaxedil.

The Efferent Vestibular System

The chapter describes the vestibular and nonvestibular signals carried by efferent neurons and how these signals might modify the information carried by afferents, and results in nonmammalian species are considered, as these provide insights into efferent function.

Neurotransmission in the inner ear

Synaptic vesicles in the cochlea.

The character of intra-cochlear synaptic vesicles was investigated in order to throw some light on transmitter identity and a catecholamine appeared to be the transmitter in the sympathetic nerve.

Ultrastructure of synapses in the lateral line canal organ.

The ultrastructure of afferent and efferent synapses on hair cells in the lateral line canal organ of hair cells of the fish Lota lota was studied, utilizing various fixation and staining techniques.

Pharmacology of the vestibular hair cell-afferent fiber synapse in the frog

The isolated, intact, membranous labyrinth of the frog has been investigated electrophysiologically in vitro to determine the nature of the transmitter substance at the synapse between the vestibular hair cells and afferent fibers, suggesting that glutamate, aspartate, or a related compound is the transmitter.

Electrical and mechanical stimulation of hair cells in the mudpuppy

The conclusion is therefore that the mechanically evoked receptor potentials in hair cells have a direct effect on the transmitter release, and the potentials are not an epiphenomenon caused by the secretory activity of the hair cells.

Neuroactive substances in inner ear extracts

  • W. F. SewellE. Mroz
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
The high-molecular-weight excitatory substance is present both in brain and in inner ear, and some extracts also contain a high- molecular-weight inhibitory substance, which is detected in extracts of innerEar, but not in brain or muscle.
...

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