Neurotransmitter release: the dark side of the vacuolar‐H+ATPase

@article{Morel2003NeurotransmitterRT,
  title={Neurotransmitter release: the dark side of the vacuolar‐H+ATPase},
  author={Nicolas Morel},
  journal={Biology of the Cell},
  year={2003},
  volume={95}
}
  • N. Morel
  • Published 1 October 2003
  • Biology
  • Biology of the Cell
The membrane domain of vacuolar H+ATPase: a crucial player in neurotransmitter exocytotic release
TLDR
It is proposed that V0 could be a sensor of intra-vesicular pH that controls the exocytotic machinery, probably regulating SNARE complex assembly during the synaptic vesicle priming step, and that, during the membrane fusion step, V0 might favor lipid mixing and fusion pore stability.
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
TLDR
V-ATPase complex is a universal proton pump and plays an important role in lysosome acidification in all types of cells and is linked to many human diseases, including neurodegenerative disorders such as Alzheimer disease, Parkinson’s disease, amyotrophic lateral sclerosis as well as neurodegnerative lysOSomal storage disorders.
Yeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore
The vacuolar H+ -ATPase (V-ATPase) is a rotary motor enzyme that acidifies intracellular organelles and the extracellular milieu in some tissues. Besides its canonical proton-pumping function,
The vacuolar proton-ATPase plays a major role in several membrane-bounded organelles in Paramecium
TLDR
The V-ATPase was found to be crucial for osmoregulation, the phagocytotic pathway and the biogenesis of dense core secretory granules in Paramecium.
Vacuolar ATPase in Physiology and Pathology: Roles in Neurobiology, Infectious Disease, and Cancer
TLDR
The involvement of pH and V-ATPase in the pathogenesis of viruses, bacteria, and fungi and the processes necessary to ensure pathogen replication are focused on.
Organelle acidification negatively regulates vacuole membrane fusion in vivo
TLDR
It is found that acute pharmacological or physiological inhibition of V-ATPase pump activity de-acidifies the vacuole lumen in living yeast cells within minutes, and time-lapse microscopy revealed that de- acidification induces vacuoles fusion rather than inhibiting it.
A new life for an old pump: V-ATPase and neurotransmitter release
TLDR
It is found that the Ca2+-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V0 sector of the V-ATPase.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 42 REFERENCES
Neurotransmitter release through the V0 sector of V‐ATPase
TLDR
The relevance of the yeast homotypic vacuole fusion model for neurotransmitter release, which involves SNARE complexes for docking synaptic vesicles at the active zones, is discussed.
Vacuolar and plasma membrane proton-adenosinetriphosphatases.
TLDR
V-ATPases function exclusively as ATP-dependent proton pumps and are the main if not the only primary energy source for numerous transport systems in these organelles in eukaryotic cells.
31P‐NMR Analysis of Synaptic Vesicles
TLDR
The cholinergic synaptic vesicles store ATP together with acetylcholine and Mg2+ essentially in free solution at an acidic pH, which means that the concept of its use as an indicator for the internal pH has been modified in the case of these organelles.
Currents through the fusion pore that forms during exocytosis of a secretory vesicle
TLDR
The patch clamp technique is used to study exocytosis of single giant secretory vesicles in mast cells of beige mice and concludes that the earliest fusion event may be the formation of a structure similar to an ion channel.
The vacuolar (H+)-ATPases — nature's most versatile proton pumps
The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intracellular membrane transport, prohormone processing
High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism
TLDR
It is shown that raised concentrations of extracellular calcium ions shift the preferred mode of exocytosis to the kiss-and-run mechanism in a calcium-concentration-dependent manner.
31P-NMR analysis of synaptic vesicles. Status of ATP and internal pH.
TLDR
It is concluded that the cholinergic synaptic vesicles store ATP together with acetylcholine and Mg2+ essentially in free solution at an acidic pH.
Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion
TLDR
V0, the membrane-integral sector of the vacuolar H+-ATPase, is identified as a target of calmodulin on yeast vacuoles and radial expansion of such a protein pore may be a mechanism for intracellular membrane fusion.
Cholinergic Synaptic Vesicles Contain a V‐Type and a P‐Type ATPase
TLDR
It is concluded that cholinergic vesicles contain a P‐ type ATPase of unknown function and a V‐type ATPase which is the proton pump.
The Amino-terminal Domain of the Vacuolar Proton-translocating ATPase a Subunit Controls Targeting and in Vivo Dissociation, and the Carboxyl-terminal Domain Affects Coupling of Proton Transport and ATP Hydrolysis*
TLDR
The results suggest that whereas targeting and in vivo dissociation are controlled by sequences located in the amino-terminal domains of the subunit a isoforms, coupling efficiency is controlled by the carboxyl-Terminal region.
...
1
2
3
4
5
...