Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.

@article{Owens1997NeurotransmitterRA,
  title={Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.},
  author={Michael J. Owens and W N Morgan and Susan J Plott and Charles B. Nemeroff},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 3},
  pages={1305-22}
}
Several new antidepressants that inhibit the serotonin (SERT) and norepinephrine transporters (NET) have been introduced into clinical practice the past several years. This report focuses on the further pharmacologic characterization of nefazodone and its metabolites within the serotonergic and noradrenergic systems, in comparison with other antidepressants. By use of radioligand binding assays, we measured the affinity (Ki) of 13 antidepressants and 6 metabolites for the rat and human SERT and… CONTINUE READING
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