Neurotransmitter-mediated inhibition of post-mortem human brain adenylyl cyclase

@article{Garlind1992NeurotransmittermediatedIO,
  title={Neurotransmitter-mediated inhibition of post-mortem human brain adenylyl cyclase},
  author={Anita Garlind and Christopher J Fowler and Irina Alafuzoff and Bengt Winblad and Richard F. Cowburn},
  journal={Journal of Neural Transmission / General Section JNT},
  year={1992},
  volume={87},
  pages={113-124}
}
The effects of a range of neurotransmitter agonists showing selectivity for receptor types inhibitorily coupled to adenylyl cyclase were compared in membrane preparations of hippocampus, frontal cortex and caudate nucleus/ striatum from previously frozen post-mortem human and rat brain. Agonists were tested against basal and forskolin stimulated activities, forskolin being a potent activator of the catalytic sub-unit of the enzyme. Of those agonists tested, only somatostatin (100 μM) and… CONTINUE READING

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