Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

@article{Zhang2007NeurotransmitterMM,
  title={Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.},
  author={Min Zhang and Josef Buttigieg and Colin A Nurse},
  journal={The Journal of physiology},
  year={2007},
  volume={578 Pt 3},
  pages={735-50}
}
The mammalian carotid body (CB) is a polymodal chemosensor which can detect low blood glucose (hypoglycaemia), leading to increased afferent discharge and activation of counter-regulatory autonomic pathways. The underlying neurotransmitter mechanisms are unknown and controversy surrounds whether the action of low glucose is direct or indirect. To address this, we used a coculture model containing functional chemosensory units of rat CB receptor (type I) cell clusters and afferent petrosal… CONTINUE READING

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