Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.

@article{Perry1977NeurotransmitterEA,
  title={Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.},
  author={Elaine K. Perry and Peter H. Gibson and G Blessed and Robert H. Perry and B. E. Tomlinson},
  journal={Journal of the neurological sciences},
  year={1977},
  volume={34 2},
  pages={247-65}
}
Reductions in 2 neurotransmitter synthesizing enzymes in brain, glutamic acid decarboxylase (GAD) and choline acetyltransferase (CAT), have been found in dementias of different origins, including senile dementia (Alzheimer type). Significant reductions in cerebral GAD have also been found in depression (unipolar). The GAD reductions did not generally appear to be localised in any specific region of the brain examined. However, the reduction of CAT in the hippocampus, relative to reductions in… CONTINUE READING
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