Neurotransmitter Dysfunction in Hepatic Encephalopathy: New Approaches and New Findings

@article{Butterworth2001NeurotransmitterDI,
  title={Neurotransmitter Dysfunction in Hepatic Encephalopathy: New Approaches and New Findings},
  author={Roger F. Butterworth},
  journal={Metabolic Brain Disease},
  year={2001},
  volume={16},
  pages={55-65}
}
Hepatic Encephalopathy (HE) is a serious neuropsychiatric condition of both acute and chronic liver failure. Acute liver failure is characterized by rapid evolution of HE and by brain edema. Portal-Systemic encephalopathy (PSE) is particularly prevalent following treatment of portal hypertension or ascites by the TIPS procedure. Available evidence currently suggests that neurotransmission changes rather than brain energy failure are the primary cause of HE. Recent studies both in autopsied… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Management of Hepatic Encephalopathy by Traditional Chinese Medicine

  • Evidence-based complementary and alternative medicine : eCAM
  • 2012
VIEW 2 EXCERPTS
CITES BACKGROUND

Role of astrocytes in manganese mediated neurotoxicity

  • BMC Pharmacology and Toxicology
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 74 REFERENCES

The astrocyte in liver disease.

  • Lancet
  • 1971
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

L-3H-arginine but not of L-3H-nitroarginine into rat brain synaptosomes

V. L. Raghavendra Rao, R. Audet, G. Therrien, R. F. Butterworth
  • J. Neurochem
  • 1994
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Increased expression

P. Bandeira, V. L. Raghavendra Rao, S. Ledoux, R. F. Butterworth
  • 1997
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Increased expression of the peripheraltype benzodiazepine receptorisoquinoline carboxamide binding protein in mRNA brain following portacaval anastomosis

P. Desjardins, P. Bandeira, V. L. Raghavendra Rao, S. Ledoux, R. F. Butterworth
  • Brain Res .
  • 1997
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Pathophysiology of hepatic encephalopathy: The ammonia hypothesis revisited

R. F. Butterworth
  • Progress in Hepatic Encephalopathy and Metabolic Nitrogen Exchange
  • 1991
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL