• Corpus ID: 19263869

Neurotransmission in human resistance arteries: contribution of alpha 1- and alpha 2-adrenoceptors but not P 2-purinoceptors.

@article{Stephens1992NeurotransmissionIH,
  title={Neurotransmission in human resistance arteries: contribution of alpha 1- and alpha 2-adrenoceptors but not P 2-purinoceptors.},
  author={N Stephens and Stuart J. Bund and E. Brian Faragher and Anthony M Heagerty},
  journal={Journal of vascular research},
  year={1992},
  volume={29 4},
  pages={
          347-52
        }
}
The contribution of postjunctional alpha 1- and alpha 2-adrenoceptors and P2-purinoceptors to the neuroeffector response was examined in isolated segments of human subcutaneous resistance arteries. Electrical field stimulation (EFS, 20 V, 0.2 ms, 1-25 Hz) elicited a maximum contractile response which was 38.2 +/- 1.6% of that elicited by exogenously applied (5 microM) noradrenaline (n = 56). Tetrodotoxin (1 microM), used to inhibit neurotransmission, reduced the electrically evoked response to… 
Neurogenic double‐peaked vasoconstriction of human gastroepiploic artery is mediated by both α1‐ and α2‐adrenoceptors
TLDR
The present results suggest that sympathetic vasoconstriction of the human gastroepiploic artery is mediated by both α1‐ and α2‐adrenoceptors postjunctionally, but not by P2X receptors.
Investigation of α1‐adrenoceptor subtypes mediating vasoconstriction in rabbit cutaneous resistance arteries
TLDR
Rabbit cutaneous resistance arteries express a prazosin‐sensitive functional α1‐adrenoceptor resembling the α1B and another low affinity site for prazoin which on the basis of the functional antagonism produced by HV723 most closely resembles theα1L‐ad Renoceptor.
Adenosine 5′‐triphosphate and neuropeptide Y are co‐transmitters in conjunction with noradrenaline in the human saphenous vein
TLDR
The present results are consistent with the working hypothesis that human sympathetic vasomotor reflexes involve the coordinated motor action of ATP, NPY, and NA acting on vascular smooth muscle cells and support the concept of sympathetic co‐transmission in the human saphenous vein.
The Sympathetic Nervous System and Small Artery Neuroeffector Function in Hypertension
TLDR
Essential hypertension is characterized by an increase in peripheral vascular resistance, at a time when the cardiac output is normal, and the relationship between vessel diameter and internal pressure means this is certainly haemodynamically crucial.
Effects of menstrual cycle and race on peripheral vascular alpha-adrenergic responsiveness.
TLDR
The luteal-phase elevation of alpha(1)-adrenergic responses may be due to elevated levels of estradiol, progesterone, or both, and the lack of luteAL-phase reduction in alpha(2)-adRenergic vasoconstriction in black women may contribute to their increased pressor responses to adrenergic stimuli.
Structure and in vitro function of human subcutaneous small arteries in mild heart failure.
TLDR
It is suggested that vascular structure and function are not different in vitro in subcutaneous arteries from placebo-treated patients with mild heart failure, which may reflect upregulation of receptor-mediated events.
Chronotropic and pressor effects of water ingestion at rest and in response to incremental dynamic exercise
TLDR
Drinking 500 ml of water before exercise reduces the chronotropic response to submaximal exercise performed below and above the ventilatory threshold, but not at maximal exercise intensities.
The effects of diabetes on sympathetic neurovascular transmission
................................................................................................................................................ 46 INTRODUCTION
Sexual dimorphism in the osmopressor response following water ingestion
TLDR
This study provides direct evidence of sexual dimorphism in the haemodynamic response to water intake and indicates that women exhibit a greater magnitude of increase in resting blood pressure after drinking a single water bolus of 500 ml.