Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons.

@article{Mattei1999NeurotoxinsTR,
  title={Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons.},
  author={C{\'e}sar Mattei and Marie Y Dechraoui and Jordi Molg{\'o} and Fr{\'e}d{\'e}ric A Meunier and A. M. Legrand and Evelyne Benoit},
  journal={Journal of neuroscience research},
  year={1999},
  volume={55 6},
  pages={666-73}
}
The effects of a C57 type ciguatoxin (CTX-3C) and two types of brevetoxins (PbTx-1 and PbTx-3), known to bind to receptor site 5 of the neuronal voltage-dependent Na+ channel-protein, were studied on the morphology of living frog myelinated axons using confocal laser scanning microscopy. During the action of CTX-3C, PbTx-1, and PbTx-3 (10-50 nM), a marked swelling of nodes of Ranvier was observed without apparent modification of internodal parts of axons. In all cases, toxin-induced nodal… CONTINUE READING

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