Neurotoxins released from interferon-gamma-stimulated human astrocytes.

  title={Neurotoxins released from interferon-gamma-stimulated human astrocytes.},
  author={Moonhee Lee and E. G. McGeer P. L. McGeer and Patrick L. Mcgeer},
Astrocytes become activated in degenerative neurological diseases. In order to gain a greater understanding of the inflammatory factors released upon activation, we stimulated adult human astrocytes with interferon-gamma and examined the resultant conditioned medium (CM) for toxicity against differentiated human neuroblastoma SH-SY5Y cells. Cell death was measured by lactate dehydrogenase release assay. We then used various treatments of the media to determine the distribution and nature of the… CONTINUE READING
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