Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling.

@article{Selvaraj2012NeurotoxininducedES,
  title={Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling.},
  author={Senthil Selvaraj and Yuyang Sun and J. Gill Watt and Shouping Wang and Saobo Lei and Lutz Birnbaumer and Brij B. Singh},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 4},
  pages={1354-67}
}
Individuals with Parkinson's disease (PD) experience a progressive decline in motor function as a result of selective loss of dopaminergic (DA) neurons in the substantia nigra. The mechanism(s) underlying the loss of DA neurons is not known. Here, we show that a neurotoxin that causes a disease that mimics PD upon administration to mice, because it induces the selective loss of DA neurons in the substantia nigra, alters Ca²⁺ homeostasis and induces ER stress. In a human neuroblastoma cell line… CONTINUE READING
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  • JJ Hoozemans, ES van Haastert, P Eikelenboom, RA de Vos, JM Rozemuller, W. Scheper
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