Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+/K(+)-ATPase involved.

@article{Huang2008NeurotoxicologicalMO,
  title={Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+/K(+)-ATPase involved.},
  author={Chun-Fa Huang and Chuan-Jen Hsu and Shing Hwa Liu and Shoei-Yn Lin-Shiau},
  journal={Toxicology letters},
  year={2008},
  volume={176 3},
  pages={188-97}
}
Methylmercury (MeHg), a potent neurotoxicant, easily passes through the blood-brain barrier (BBB), accumulates in the brain regions and causes severe irreversible damage. However, the neurotoxic effects and action mechanisms of MeHg are still unclear, especially in low-dose and long-term exposure. In this study, we attempted to explore the toxic effects of low-dose MeHg (0.05 mg/kg/day), which was the possible exposed dose by ingestion in MeHg-contaminated areas, on the time course of changes… CONTINUE READING
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