Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles.

@article{Hu2010NeurotoxicologicalEA,
  title={Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles.},
  author={Renping Hu and Xiaolan Gong and Yanmei Duan and Na Li and Yi Che and Yaling Cui and Min Zhou and Chao Liu and Han Wang and Fashui Hong},
  journal={Biomaterials},
  year={2010},
  volume={31 31},
  pages={8043-50}
}
Titanium dioxide nanoparticles (TiO(2) NPs) are now in daily use including popular sunscreens, toothpastes, and cosmetics. However, the effects of TiO(2) NPs on human body, especially on the central nervous system, are still unclear. The aim of this study was to determine whether TiO(2) NPs exposure results in persistent alternations in nervous system function. ICR mice were exposed to TiO(2) NPs through intragastric administration at 0, 5, 10 and 50 mg/kg body weight every day for 60 days. The… CONTINUE READING