Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways.

@article{Kirby2001NeurotoxicityOT,
  title={Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways.},
  author={Michael L Kirby and Rebecca L Barlow and Jeffrey R Bloomquist},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={61 1},
  pages={100-6}
}
Changes in biochemical status of nerve terminals in the corpus striatum, one of the primary brain regions affected in Parkinson's disease, were studied in groups of C57BL/6 mice treated by ip injection three times over a 2-week period with 3--100 mg/kg heptachlor. On average, the maximal rate of striatal dopamine uptake increased > 2-fold in mice treated at doses of 6 mg/kg heptachlor and 1.7-fold at 12 mg/kg heptachlor. Increases in maximal rate of striatal dopamine uptake were attributed to… CONTINUE READING

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