Neurotoxicity of intrathecal Shiga toxin 2 and protection by intrathecal injection of anti-Shiga toxin 2 antiserum in rabbits.

@article{Fujii1998NeurotoxicityOI,
  title={Neurotoxicity of intrathecal Shiga toxin 2 and protection by intrathecal injection of anti-Shiga toxin 2 antiserum in rabbits.},
  author={Junko Fujii and Yoshimasa Kinoshita and Yoshihiro Yamada and Takashi Yutsudo and Toru Kita and Tae Takeda and Shin-ichi Yoshida},
  journal={Microbial pathogenesis},
  year={1998},
  volume={25 3},
  pages={
          139-46
        }
}
The initial brain lesions in rabbits given intravenous Shiga toxin 2 (Stx2) were noted at 24 h in an area around the third ventricle (Fujii et al., Infect Immun 1996, 64: 5053-60). This result implied that Stx2 is present in the cerebrospinal fluid (CSF) despite the fact that the toxin was administered intravenously. We measured Stx2 activity in CSF by using a Vero cell cytotoxicity assay at various times after an intravenous injection of Stx2. Stx2 was detected from 2 h after the injection… CONTINUE READING