Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

@article{Yankner1989NeurotoxicityOA,
  title={Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.},
  author={Bruce A. Yankner and Lyn Dawes and Shannon J. Fisher and L. Villa-Komaroff and Mary Lou Oster-Granite and Rachael Lee Neve},
  journal={Science},
  year={1989},
  volume={245 4916},
  pages={417-20}
}
Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a by-product of that process is unknown. Pheochromocytoma (PC12) and fibroblast (NIH 3T3) cell lines were transfected with portions of the gene for the human amyloid precursor protein. Stable PC12 cell transfectants expressing a specific amyloid-containing fragment of the precursor protein gradually degenerated… CONTINUE READING
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