Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.

@article{McDonald1988NeurotoxicityON,
  title={Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.},
  author={J. W. McDonald and Faye Sarah Silverstein and Michael V Johnston},
  journal={Brain research},
  year={1988},
  volume={459 1},
  pages={200-3}
}
The neurotoxic lesion produced by direct injection of 25 nmol of N-methyl-D-aspartate (NMDA) into the corpus striatum of 7-day-old rats was compared to the effects of injecting 75 nmol into the striatum or hippocampus of adults. The area of histopathology in the immature striatum was 21 X larger than the striatal lesion in adults. Damage from NMDA injected into the immature striatum also extended into the dorsal hippocampus and produced an area of destruction which was 16 X larger than observed… CONTINUE READING

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