Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases.

@article{Burke2004NeurotoxicityOM,
  title={Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases.},
  author={William M. J. Burke and Shu Wen Li and Hyung D. Chung and David A. Ruggiero and Bruce S. Kristal and Eugene M. Johnson and Patricia A. Lampe and V B Sameer Kumar and Mark W. Franko and Evelyn A Williams and Daniel S Zahm},
  journal={Neurotoxicology},
  year={2004},
  volume={25 1-2},
  pages={101-15}
}
The monoamine oxidase (MAO) metabolites of norepinephrine (NE) or epinephrine (EPI) and of dopamine (DA) are 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively. The toxicity of these catecholamine (CA) MAO metabolites was predicted over 50 years ago. However, until our recent chemical synthesis of these CA aldehyde metabolites, the hypothesis about their toxicity could not be tested. The present paper reviews recent knowledge gained about these… CONTINUE READING

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