Neurotoxicity of Anesthetic Drugs in the Developing Brain

@article{Stratmann2011NeurotoxicityOA,
  title={Neurotoxicity of Anesthetic Drugs in the Developing Brain},
  author={Greg Stratmann},
  journal={Anesthesia \& Analgesia},
  year={2011},
  volume={113},
  pages={1170–1179}
}
  • G. Stratmann
  • Published 1 November 2011
  • Medicine
  • Anesthesia & Analgesia
Anesthesia kills neurons in the brain of infantile animals, including primates, and causes permanent and progressive neurocognitive decline. The anesthesia community and regulatory authorities alike are concerned that is also true in humans. In this review, I summarize what we currently know about the risks of pediatric anesthesia to long-term cognitive function. If anesthesia is discovered to cause cognitive decline in humans, we need to know how to prevent and treat it. Prevention requires… 

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The aim of this review is to provide the reader with a summary of recent human cohort studies and discuss their limitations and weaknesses to provide evidence as to if and how general anesthesia impairs neurocognition and behaviour in infants and young children.

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...

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