Neurotoxicity of β-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis.

@article{Kawahara2010NeurotoxicityO,
  title={Neurotoxicity of β-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis.},
  author={Masahiro Kawahara},
  journal={Current pharmaceutical design},
  year={2010},
  volume={16 25},
  pages={
          2779-89
        }
}
Numerous studies have indicated that Alzheimer's amyloid-β protein (Aβ) causes the degeneration of synapses and neurons, finally inducing the pathogenesis of Alzheimer's disease (AD). Recent approaches have emphasized the importance of Aβ oligomerization which enhances its neurotoxicity and synaptotoxicity. Our work as well as other groups' research have demonstrated that Aβ oligomers are directly incorporated into neuronal membranes and form calcium-permeable ion channels (amyloid channels… CONTINUE READING
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