Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.

  title={Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.},
  author={Patr{\'i}cia Silva Ferreira and Tiago Bernandes Nogueira and Vera Marisa Costa and Paula S Branco and Luisa M Ferreira and Eduarda Fernandes and Maria de Lourdes Bastos and Andreas Meisel and F{\'e}lix Carvalho and J P Capela},
  journal={Toxicology letters},
  volume={216 2-3},
"Ecstasy" (3,4-methylenedioxymethamphetamine or MDMA) is a widely abused recreational drug, reported to produce neurotoxic effects, both in laboratory animals and in humans. MDMA metabolites can be major contributors for MDMA neurotoxicity. This work studied the neurotoxicity of MDMA and its catechol metabolites, α-methyldopamine (α-MeDA) and N-methyl-α-methyldopamine (N-Me-α-MeDA) in human dopaminergic SH-SY5Y cells differentiated with retinoic acid and 12-O-tetradecanoyl-phorbol-13-acetate… CONTINUE READING
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