Neurotoxicity modeling for risk assessment.

  title={Neurotoxicity modeling for risk assessment.},
  author={Ralph L. Kodell and James J. Chen and David W. Gaylor},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={22 1},
The setting of acceptable exposure levels for neurotoxicants has followed the traditional approach of dividing experimental no-observed-adverse-effect-levels (NOAELs) by safety/uncertainty factors. NOAELs are believed by many toxicologists to represent levels having zero or negligible risk, while uncertainty factors are used to account for a number of sources of variation. Although the use of NOAELs in this manner has been criticized because of their imprecise quantitative definition, NOAELs… CONTINUE READING