Neurotoxicity induced by methamphetamine-heroin combination in PC12 cells.

  title={Neurotoxicity induced by methamphetamine-heroin combination in PC12 cells.},
  author={Xiang Tian and Q. M. Ru and Q F Xiong and Kai Xin Yue and Lin Chen and Baomiao Ma and Weimin Gan and Yuanren Si and Huqiao Xiao and Chao-ying Li},
  journal={Neuroscience letters},
Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. The combination of psychostimulants and opioids produces more serious effects than either drug alone and is responsible for numerous deaths. In recent years, owing to its increased use, methamphetamine (METH), a psychostimulant, has become a popular choice for use in combination with opioids, especially heroin. However, little is known about the neurotoxicity of METH/heroin combination. The aims… CONTINUE READING