Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.

@article{Lipton1997NeurotoxicityAW,
  title={Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.},
  author={Stuart Lipton and Won Ki Kim and Young Bin Choi and S K Praveen Kumar and Danielle M D'Emilia and Posina V. Rayudu and Derrick R. Arnelle and Jonathan S. Stamler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 11},
  pages={5923-8}
}
Severely elevated levels of total homocysteine (approximately millimolar) in the blood typify the childhood disease homocystinuria, whereas modest levels (tens of micromolar) are commonly found in adults who are at increased risk for vascular disease and stroke. Activation of the coagulation system and adverse effects of homocysteine on the endothelium and vessel wall are believed to underlie disease pathogenesis. Here we show that homocysteine acts as an agonist at the glutamate binding site… CONTINUE READING
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