Neurotoxicity assessment using zebrafish.

@article{Parng2007NeurotoxicityAU,
  title={Neurotoxicity assessment using zebrafish.},
  author={Chuenlei Parng and Nicole M. Roy and Christopher Ton and Yingxin Lin and Patricia McGrath},
  journal={Journal of pharmacological and toxicological methods},
  year={2007},
  volume={55 1},
  pages={
          103-12
        }
}
INTRODUCTION Transparency is a unique attribute of zebrafish that permits direct assessment of drug effects on the nervous system using whole mount antibody immunostaining and histochemistry. METHODS To assess pharmacological effects of drugs on the optic nerves, motor neurons, and dopaminergic neurons, we performed whole mount immunostaining and visualized different neuronal cell types in vivo. In addition, we assessed neuronal apoptosis, proliferation, oxidation and the integrity of the… CONTINUE READING

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