Neurotoxicity and pharmacokinetics of intrathecal perfusion of ACNU in dogs

  title={Neurotoxicity and pharmacokinetics of intrathecal perfusion of ACNU in dogs},
  author={Masato Kochi and Jun-ichi Kuratsu and Yoshiaki Mihara and Shuichi Takaki and Nagamu Inoue and Noriyoshi Sueyoshi and Sadashige Uemura and Yukitaka Ushio},
  journal={Cancer research},
  volume={50 10},
To test the feasibility of intrathecal perfusion of ACNU (3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitro sou rea hydrochloride) in the treatment of subarachnoid dissemination of malignant glioma, the neurotoxicity and pharmacokinetics of ACNU were studied in dogs. ACNU [1-2 mg dissolved in 10-20 ml of lactated Ringer's solution or artificial cerebrospinal fluid (CSF)] was administered via the right lateral ventricle by constant drip infusion and CSF was drained by lumbar… CONTINUE READING


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