Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons.

@article{Son2005NeurotoxicityAB,
  title={Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons.},
  author={Jin H Son and Hibiki Kawamata and Myung Sik Yoo and Daejin J Kim and Young Ki Lee and Sooyoul Kim and Valina L. Dawson and Hui Zhang and David Sulzer and Shangchuan Yang and M. Flint Beal and Lorraine A Degiorgio and Hong Sung Chun and Hillier L. Baker and Chuansheng Peng},
  journal={Journal of neurochemistry},
  year={2005},
  volume={94 4},
  pages={
          1040-53
        }
}
Septin 5, a parkin substrate, is a vesicle- and membrane-associated protein that plays a significant role in inhibiting exocytosis. The regulatory function of Septin 5 in dopaminergic (DAergic) neurons of substantia nigra (SN), maintained at relatively low levels, has not yet been delineated. As loss of function mutations of parkin are the principal cause of a familial Parkinson's disease, a prevailing hypothesis is that the loss of parkin activity results in accumulation of Septin 5 which… CONTINUE READING
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