Neurotoxicity after spinal anaesthesia induced by serial intrathecal injections of magnesium sulphate. An experimental study in a rat model.

@article{Chanimov1997NeurotoxicityAS,
  title={Neurotoxicity after spinal anaesthesia induced by serial intrathecal injections of magnesium sulphate. An experimental study in a rat model.},
  author={Michael Chanimov and Mathias L Cohen and Y Grinspun and Morley Herbert and Roland Reif and Ian Kaufman and Murat Bahar},
  journal={Anaesthesia},
  year={1997},
  volume={52 3},
  pages={223-8}
}
We have previously demonstrated in a rat model that the lumbar intrathecal injection of 0.02 ml 6.3% magnesium sulphate, a concentration iso-osmolar with rat plasma, produces a state of spinal anaesthesia and general sedation which reversed completely after 6 h, without evidence of neurotoxicity, immediately or during the week thereafter. Using the same model and five groups of six animals in each, we administered the same volume and concentration of magnesium sulphate and compared its clinical… CONTINUE READING
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