Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats

  title={Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats},
  author={Chi.-won Song and Kisok Kim and Younjoo Park and Jung-yup Kim and Seong-Ho Koh and Juwhan Kim and Yong-Soon Kim and Se Hoon Kim and Yong Chul Kim and Ki-Hwa Yang and Haikwan Jung},
  journal={Journal of Toxicologic Pathology},
1,3-dichoro-1,2-propanediol (1,3-DCP) is a contaminant of acid-hydrolyzed vegetable protein and a chlorinated compound used in the fabrication of industrial products such as hard resins, celluloid or paints. Several reports have suggested that chronic exposure to 1,3-DCP could produce neurotoxicity in vitro or in neurobehavioral aspects of experimental animals. The present study further explored the in vitro neurotoxic effects of 0.1-100 μM 1,3-DCP on PC12 and N18D3 cell lines. In addition, to… Expand

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